Edvard Weie was born in Copenhagen, Denmark. His father went away when Edvard was still very young and left his family in poverty. To help out, he would deliver newspapers every morning before school and later worked as a house painter. Despite the hardship, he was able to take art lessons. When he came of age, he went to Copenhagen to apply for admission to the Royal Danish Academy of Fine Arts, but was not accepted.
It was not until 1905, when he was already twenty-five years old, that he was able to enter the Kunstnernes Frie Studieskoler, operated by Kristian Zahrtmann (1843–1917). It was there that he was introduced to modern art. He became a favored student and accompanied Zahrtmann on a trip to Italy in 1907, but returned prematurely when they had a falling-outBack in Denmark, he painted a series of interiors and landscapes. From 1911 to 1920, he would spend part of every year painting on the island of Christiansø. It was there he met the Swedish painter Karl Isakson (1878–1922). After Isakson's early death in 1922, Weie made an extensive study of his uses of color, and applied what he learned to his own works